The Nation's Leader in Minimally Invasive Colorectal Care

Expert, World-Class Colorectal Surgery in Los Angeles.
Surgeon wearing protective mask, face shield, and surgical cap operating a medical device during surgery.
18+ years performing minimally invasive surgeries. 10,000+ patients seen and 6,000+ surgeries.
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Healing, Preserving, and Restoring Colorectal Function

Living with colorectal conditions can be painful, isolating, and overwhelming. The good news is that you don’t have to face them alone. Dr. Karen Zaghiyan, MD, FACS, FASCRS, is widely recognized as the best minimally invasive colorectal surgeon in Los Angeles and a national leader in colon and rectal surgery, laparoscopic colectomy, and robotic colorectal cancer surgery.

Dr. Zaghiyan delivers innovative solutions for a full spectrum of conditions, from everyday issues like hemorrhoids, anal fissures, and fistulas to complex diagnoses such as colon cancer, rectal cancer, Crohn’s disease, ulcerative colitis, diverticulitis, and rectal prolapse. Her expertise also includes advanced procedures such as colonoscopy, robotic colorectal surgery, J-pouch surgery, and transanal minimally invasive surgery (TAMIS), providing patients with access to leading-edge treatments that prioritize healing, comfort, and the preservation of function.

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Why Patients Trust Dr. Zaghiyan

Dr. Zaghiyan’s practice is built on the belief that colorectal care should never be one-size-fits-all, tailoring every compassionate approach to each patient’s needs. Her mission is simple: to help you find relief, preserve your health, and feel whole again.

about the doctor
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for Minimally Invasive Colorectal Care

Patients turn to Dr. Zaghiyan for:

01

Nationally Recognized Leader & Surgical Pioneer

02

Practice-Changing Research & Global Impact

03

Compassionate, Personalized & Minimally Invasive Care

Colorectal Conditions 
We Treat

Dr. Karen Zaghiyan, widely considered the best colorectal surgeon in Los Angeles, believes that colorectal care should always be highly personalized and as minimally invasive as possible. Whether you’re seeking relief from hemorrhoids, struggling with Crohn’s disease, or facing a diagnosis of rectal cancer, Dr. Zaghiyan combines compassionate care with advanced minimally invasive and robotic techniques to restore function, comfort, and quality of life.

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Close-up of a medical model showing the inside of the colon with polyps and abnormal growths.
colorectal Cancer
01
A diagnosis of colorectal cancer can be overwhelming, but you don’t have to face it alone. As the best rectal cancer surgeon in Los Angeles and the best colon cancer specialist in Los Angeles, Dr. Zaghiyan prioritizes sphincter-preserving, organ-sparing techniques whenever possible. She is one of a few international leading experts in transanal total mesorectal excision (taTME), a minimally invasive approach to rectal cancer surgery. She is also skilled in transanal minimally invasive surgery (TAMIS), robotic colon cancer surgery, robotic rectal cancer surgery, intersphincteric proctectomy, and organ preservation strategies, delivering the best rectal cancer treatment in Los Angeles with precision and expertise.
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Anal Fistula
03
Anal fistulas require expert evaluation and precise surgical management to avoid complications. As the best anal fistula surgeon in Los Angeles, Dr. Zaghiyan offers the full spectrum of advanced treatments, including laser anal fistula closure (FiLaC), the LIFT procedure, endorectal advancement flap, and rectovaginal fistula repair. Her approach focuses on preserving continence while resolving infection and restoring normal function.
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Crohn’s Disease
05
Managing Crohn’s disease requires specialized expertise. As the best Crohn’s disease surgeon in Los Angeles, Dr. Zaghiyan offers advanced surgical options when medical management is no longer effective. These include robotic ileocolic resection, robotic colectomy, and robotic J-pouch surgery, making her one of the most sought-after experts for the best Crohn’s disease surgery in Los Angeles and Cedars-Sinai Medical Center.
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Diverticulitis
07
Recurring or complicated diverticulitis often requires surgery. Karen Zaghiyan, MD, known as the best diverticulitis surgeon in Los Angeles, performs advanced robotic colectomy procedures that minimize incisions, reduce recovery time, and preserve bowel function. Patients trust her as the best diverticulitis specialist in Los Angeles for her precision, innovation, and excellent outcomes.
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Pilonidal Cyst
09
For patients struggling with painful or recurrent pilonidal cysts, Dr. Zaghiyan offers innovative, minimally invasive pilonidal disease treatments. As the best pilonidal cyst surgeon in Los Angeles, she performs laser pilonidal surgery (SiLaC), and pilonidal flap surgery at Cedars-Sinai Medical Center, helping patients heal quickly and avoid recurrence.
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Rectal Prolapse
11
For patients experiencing rectal prolapse, Dr. Zaghiyan is the best rectal prolapse surgeon in Los Angeles, offering advanced minimally invasive procedures such as robotic rectopexy with or without mesh, robotic rectocele repair, robotic enterocele repair, and combined robotic multi-organ prolapse surgery. These techniques deliver durable results with faster recovery and preserved function.
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Transanal Minimally Invasive Surgery (TAMIS)
13
TAMIS is an advanced approach for removing rectal tumors and polyps with minimal disruption. As the best TAMIS surgeon in Los Angeles, Karen Zaghiyan, MD, offers this leading-edge option as part of her commitment to organ-preserving care and advanced cancer treatment.
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Hereditary Colorectal Cancer: Lynch Syndrome, Familial Polyposis, MYH Polyposis
15
If you have a family history of colon or rectal cancer, multiple polyps, or known genetic mutations, you may be at risk for hereditary colorectal cancer. Dr. Zaghiyan is highly specialized in diagnosing and managing hereditary syndromes such as Lynch syndrome, FAP, and MYH polyposis. She offers comprehensive surveillance, preventive strategies, and advanced surgical options, including minimally invasive partial or total proctocolectomy with J-pouch reconstruction, and organ-sparing techniques, to reduce cancer risk and protect your long-term health.
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Anal Fissure
02
If you suffer from painful bowel movements, bleeding, or tearing, you may have an anal fissure. Dr. Zaghiyan is recognized as the best anal fissure specialist in Los Angeles, offering non-surgical and minimally invasive treatments, such as Botox therapy, PRP (platelet-rich plasma) injections, and sphincterotomy surgery when needed. Treatments are tailored to relieve pain, promote healing, and prevent recurrence.
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Colonoscopy
04
As both a diagnostic and preventive tool, colonoscopy remains the gold standard for identifying colon cancer, polyps, and other conditions early. At the best colonoscopy clinic in Los Angeles, Dr. Zaghiyan is recognized as the best colonoscopy doctor in Los Angeles, offering state-of-the-art technology and compassionate care to make this critical screening comfortable and effective.
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Ulcerative Colitis
06
For patients with ulcerative colitis who require surgery, Dr. Karen Zaghiyan offers robotic J-pouch surgery (IPAA) and other advanced surgical options designed to eliminate disease, avoid permanent ileostomy when possible, and restore bowel function while preserving quality of life. Recognized as the best ulcerative colitis surgeon in Los Angeles, she brings cutting-edge, minimally invasive solutions to those seeking the best ulcerative colitis treatment at Cedars-Sinai Medical Center in Los Angeles.
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Hemorrhoids
08
Hemorrhoids are one of the most common conditions Dr. Zaghiyan treats, and she is recognized as the best hemorrhoid specialist in Los Angeles for offering painless, non-invasive hemorrhoid treatments. Options include hemorrhoid sclerotherapy, infrared coagulation, rubber band ligation, laser hemorrhoid surgery, transanal hemorrhoidal dearterialization, and anal skin tag removal. As the best hemorrhoid treatment in Los Angeles, her approach avoids unnecessary surgery and delivers lasting relief.
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Fecal Incontinence & Pelvic Floor Disorders
10
Loss of bowel control or pelvic floor dysfunction can deeply affect quality of life. As the best pelvic floor specialist in Los Angeles, Dr. Zaghiyan provides comprehensive treatments, including Emsella pelvic floor therapy, Solesta injection, sacral neuromodulation (InterStim), and anal sphincter repair. ​​Diagnostic testing, such as ultrasound and manometry, may be used to guide individualized treatments. She is widely trusted as the best fecal incontinence specialist in Los Angeles, restoring dignity and function through advanced therapies.
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Robotic Colorectal Surgery
12
As a national leader in robotic colorectal surgery, Karen Zaghiyan, MD, is recognized as the best robotic colorectal surgeon in Los Angeles. Her expertise includes robotic colectomy, robotic rectopexy, robotic ileocolic resection, and robotic J-pouch surgery, ensuring patients receive the most advanced surgical options available with smaller incisions, less pain, and faster return to normal activities. Dr. Zaghiyan provides these procedures at the nationally renowned Cedars-Sinai Medical Center.
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Anal Neoplasia
14
Anal neoplasia involves abnormal cell growth in the anal canal, which can range from precancerous lesions to early anal cancer. As a leading expert in anal dysplasia and early anal cancer management, Dr. Zaghiyan provides thorough evaluation and state-of-the-art treatments, including high-resolution anoscopy (HRA), targeted excision, and advanced minimally invasive therapies. Her approach is focused on accurate diagnosis, preventing progression, and delivering effective, organ-preserving care.
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Second Opinions for Colorectal Diagnoses
16
Facing a complex colorectal diagnosis or a recommended surgery for one can leave you with uncertainty and searching for answers. Thankfully, Dr. Zaghiyan offers expert second opinions via one-on-one telehealth consultations, allowing you to receive high-level insights with clarity from a world-renowned colorectal surgeon without traveling. The process is straightforward: you submit your imaging and medical records in advance, Dr. Zaghiyan personally reviews them, and then meets with you to discuss findings, options, and next steps. Second-opinion consultations are billed out of pocket and cannot be submitted to insurance. While these educational consultations do not establish a formal doctor/patient relationship, patients desiring to establish treatment with Dr. Zaghiyan may travel to Los Angeles to establish care.
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Restoring Your Life with Minimally Invasive Colorectal Care

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Our Minimally Invasive Colorectal Surgery Location & Areas We Serve

Our premier colorectal surgery practice is located in the heart of Los Angeles at 8737 Beverly Blvd, Suite 101, Los Angeles, CA 90048, across the street from Cedars-Sinai Medical Center main campus. All major colorectal surgeries are performed at Cedars-Sinai, while minor anorectal procedures may be performed at the ambulatory surgery center. From this centrally situated office, Dr. Zaghiyan is proud to serve patients from Beverly Hills, West Hollywood, Century City, Santa Monica, Brentwood, Culver City, and across greater Los Angeles. Recognized for her advanced training, minimally invasive expertise, and commitment to preserving function, Dr. Zaghiyan provides patients with care that represents the very best in modern colorectal surgery. Patients travel from across Southern California and the rest of the United States to receive her personalized, world-class treatment in a discreet, state-of-the-art setting.

Ready to receive world-class colorectal care that prioritizes your health, function, and quality of life? Schedule a consultation with the best colorectal surgeon in Los Angeles today.

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LA’s Expert Colorectal Specialist
Karen Zaghiyan, MD
LA’s Expert Colorectal Specialist
Karen Zaghiyan, MD

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For patients who need an urgent consultation, it is best to call us at (310) 289-9224. Otherwise, please complete and submit the form below and a member of our staff will contact you shortly.

Location
& Hours
hours
MON 9:00 a.m. - 5:00 p.m.
TUE 9:00 a.m. - 5:00 p.m.
WED 9:00 a.m. - 5:00 p.m.
THUR 9:00 a.m. - 5:00 p.m.
FRI 9:00 a.m. - 5:00 p.m.
Practice Info
Location
8737 Beverly Blvd, Suite 101
Los Angeles, CA 90048
contact
Phone: (310) 289-9224
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hours
MON - FRI 9:00am - 5:00pm
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Crohn's DiseaseDiverticulitisFecal IncontinenceHemorrhoids
J Pouch SurgeryPilonidal CystRectal CancerRectal Prolapse
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